A Deterministic Mathematical Model of Meningitis Transmission Dynamics with Vaccination and Screening

Authors

DOI:

https://doi.org/10.25077/jmua.14.1.14-30.2025

Keywords:

Basic Reproduction Number, Meningitis Modelling Disease, Routh-Hurwitz Criterion

Abstract

This study aims to examine the mathematical model of meningitis transmission as a deterministic model. The model includes five compartments: susceptible (S), carrier (C), infected (I), treatment (T), and recovered (R). We also consider vaccination and screening as interventions in disease transmission. In this work, we obtained two equilibrium points: disease-free equilibrium point and endemic equilibrium point. The next generation matrix is employed to compute the basic reproduction numbers ($R_0$). We also analyzed the sensitivity of parameters concerning $R_0$. If $R_0 < 1$, then the disease-free equilibrium point exists and is locally stable, whereas the endemic equilibrium point exists when $R_0 > 1$ and is locally stable if the Routh-Hurwitz criterion is satisfied. We use the Runge-Kutta 4th order method to confirm the stability properties of the equilibrium points and also show that vaccination and screening affect the transmission dynamics of Meningitis

Author Biographies

Muh Ikhsan Amar, Insitut Teknologi Bacharuddin Jusuf Habibie

Ilmu Komputer

Muhammad Rifki Nisardi, Insitut Teknologi Bacharuddin Jusuf Habibie

Teknik Metalurgi

Muhammad Fadhil Nurahmad, Insitut Teknologi Bacharuddin Jusuf Habibie

Matematika

References

D. Aldila et al., “A mathematical study on the spread of COVID-19 considering social distancing and rapid assessment: The case of Jakarta, Indonesia,†Chaos, Solitons & Fractals, vol. 139, p. 110042, Oct. 2020, doi: 10.1016/j.chaos.2020.110042.

Attaullah and M. Sohaib, “Mathematical modeling and numerical simulation of HIV infection model,†Results in Applied Mathematics, vol. 7, p. 100118, Aug. 2020, doi: 10.1016/j.rinam.2020.100118.

A. Abadi, M. Fakhruddin, R. Artiono, and B. P. Prawoto, “Measles Transmission Model with Vaccination and Hospitalization Treatments,†CBMS, vol. 3, no. 2, pp. 127–134, May 2021, doi: 10.5614/cbms.2020.3.2.4.

F. K. Alalhareth, U. Atta, A. H. Ali, A. Ahmad, and M. H. Alharbi, “Analysis of Leptospirosis transmission dynamics with environmental effects and bifurcation using fractional-order derivative,†Alexandria Engineering Journal, vol. 80, pp. 372–382, Oct. 2023, doi: 10.1016/j.aej.2023.08.063.

S. Adeyemo, A. Sangotola, and O. Korosteleva, “Modeling Transmission Dynamics of Tuberculosis–HIV Co-Infection in South Africa,†Epidemiologia, vol. 4, no. 4, pp. 408–419, Oct. 2023, doi: 10.3390/epidemiologia4040036.

M. Fakhruddin et al., “Investigation of a measles transmission with vaccination: a case study in Jakarta, Indonesia,†MBE, vol. 17, no. 4, pp. 2998–3018, 2020, doi: 10.3934/mbe.2020170.

M. Kizito and J. Tumwiine, “A Mathematical Model of Treatment and Vaccination Interventions of Pneumococcal Pneumonia Infection Dynamics,†Journal of Applied Mathematics, vol. 2018, pp. 1–16, 2018, doi: 10.1155/2018/2539465.

M. R. Nisardi, K. Kasbawati, K. Khaeruddin, A. Robinet, and K. Chetehouna, “Fractional Mathematical Model of Covid-19 with Quarantine,†InPrime:Ind.Jour.Pure.Applied.Math, vol. 4, no. 1, pp. 33–48, Apr. 2022, doi: 10.15408/inprime.v4i1.23719.

P. Widyastuti, H. N. Utami, and M. F. Anugrah, “Meningitis Bakterial: Epidemiologi, Patofisiologi, Penatalaksanaan,†vol. 2, no. 2, 2023.

I. Abdullahi Baba et al., “Analysis of meningitis model: A case study of northern Nigeria,†AIMS Bioengineering, vol. 7, no. 4, pp. 179–193, 2020, doi: 10.3934/bioeng.2020016.

S. Sulma, S. Toaha, and K. Kasbawati, “Stability Analysis of Mathematical Models of the Dynamics of Spread of Meningitis with the Effects of Vaccination, Campaigns and Treatment,†Jurnal Matematika, Statistika dan Komputasi, vol. 17, pp. 71–81, Aug. 2020, doi: 10.20956/jmsk.v17i1.10031.

C. Türkün, M. Gölgeli, and F. M. Atay, “A mathematical interpretation for outbreaks of bacterial meningitis under the effect of time-dependent transmission parameters,†Nonlinear Dyn, vol. 111, no. 15, pp. 14467–14484, Aug. 2023, doi: 10.1007/s11071-023-08577-6.

S. S. Musa, S. Zhao, N. Hussaini, A. G. Habib, and D. He, “Mathematical modeling and analysis of meningococcal meningitis transmission dynamics,†Int. J. Biomath., vol. 13, no. 01, p. 2050006, Jan. 2020, doi: 10.1142/S1793524520500060.

M. J. F. Martínez, E. G. Merino, E. G. Sánchez, J. E. G. Sánchez, A. M. D. Rey, and G. R. Sánchez, “A Mathematical Model to Study the Meningococcal Meningitis,†Procedia Computer Science, vol. 18, pp. 2492–2495, 2013, doi: 10.1016/j.procs.2013.05.426.

H. E. Bashir, M. Laundy, and R. Booy, “Diagnosis and treatment of bacterial meningitis,†2003.

Direktorat Jenderal Pencegahan dan Pengendalian Penyakit Kemenkes RI, “FAQ MENINGITIS MENINGOKOKUS.†2023. Accessed: Feb. 10, 2024. [Online]. Available: https://infeksiemerging.kemkes.go.id/document/frequently-asked-questions-meningitis-meningokokus/

J. K. K. Asamoah, F. Nyabadza, B. Seidu, M. Chand, and H. Dutta, “Mathematical Modelling of Bacterial Meningitis Transmission Dynamics with Control Measures,†Computational and Mathematical Methods in Medicine, vol. 2018, pp. 1–21, 2018, doi: 10.1155/2018/2657461.

K. G. Varshney and Y. K. Dwivedi, “Mathematical Modelling of Influenza-Meningitis under the Quarantine effect of influenza,†2021.

B. S. Kotola and T. T. Mekonnen, “Mathematical model analysis and numerical simulation for codynamics of meningitis and pneumonia infection with intervention,†Sci Rep, vol. 12, no. 1, p. 2639, Feb. 2022, doi: 10.1038/s41598-022-06253-0.

F. Keshtkar, G. H. Erjaee, and M. Boutefnouchet, “On stability of equilibrium points in nonlinear fractional differential equations and fractional Hamiltonian systems,†Complexity, vol. 21, Jul. 2014, doi: 10.1002/cplx.21581.

N. Chitnis, J. Hyman, and J. Cushing, “Determining Important Parameters in the Spread of Malaria Through the Sensitivity Analysis of a Mathematical Model,†Bulletin of mathematical biology, vol. 70, pp. 1272–1296, Jan. 2008, doi: 10.1007/s11538-008-9299-0.

Downloads

Published

31-01-2025

Issue

Section

Articles