SUATU MODEL MATEMATIKA INTERAKSI SEL KANKER NASOFARING DENGAN VIRUS EPSTEIN-BARR (EBV) DENGAN INTERVENSI KEMOTERAPI
DOI:
https://doi.org/10.25077/jmu.10.4.499-509.2021Abstract
Kanker nasofaring (KNF) merupakan kanker yang berasal dari sel epitel nasofaring yang berada di rongga belakang hidung dan di belakang langit-langit rongga mulut. Karsinoma nasofaring sangat erat kaitannya dengan infeksi Epstein Barr Virus (EBV). Pengobatan kanker nasofaring dapat ditempuh memlaui berbagai cara, seperti operasi atau pembedahan, radioterapi, kemoterapi, terapi hormon, dan imunoterapi. Pada makalah ini disusun model matematika perkembangan sel nasofaring akibat infeksi virus EBV dengan intervensi kemoterapi. Model berbentuk sistem persamaan diferensial biasa berdimensi empat yang mendeskripsikan interaksi sel sehat, virus, sel terinfeksi, dan sel karsinoma invasif. Selanjutnya dibahas eksistensi dan analisis kestabilan lokal dari titik ekuilibrium yang menunjukkan bahwa tingkat infeksi dan intervensi pengobatan merupakan faktor penting dalam perkembangan kanker nasofaring. Simulasi numerik diberikan untuk memverifikasi teorema yang diperoleh.
Kata Kunci: Kanker nasofaring, model matematika, kestabilan lokal
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References
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